Chimeric Antigen Receptor T Cell Therapies For Multiple Myeloma

T cells expressing the car used in this work.

Chimeric antigen receptor t cell therapies for multiple myeloma.

B cell maturation antigen bcma is expressed in most cases of mm. In the past few years chimeric antigen receptor car modified t cell therapy for mm. Disease settings where clinical evaluation of car t cell therapy has been reported advanced relapse refractory disease. T cell therapies are a promising approach for treating mm with a mechanism of action different than those of standard mm treatments.

Cars are artificial fusion proteins that incorporate an antigen recognition domain and t cell signaling domains. There is an unmet need to develop novel therapies for refractory relapsed mm. Dimopoulos 8 paulo lucio 9 joan bladé 10 michel delforge 11 roman. 5 6 18 20 cars are.

B cell maturation antigen bcma is a validated target for chimeric antigen receptor car t cell therapy in multiple myeloma mm. 5 6 18 t cells expressing a car can specifically recognize a targeted antigen which is an advantage of car t cells over nonspecific cellular therapies such as allogeneic hematopoietic stem cell transplantation. Multiple myeloma mm is a nearly always incurable malignancy of plasma cells so new approaches to treatment are needed. We conducted the first in humans clinical trial of chimeric antigen receptor car t cells targeting bcma.

A consensus statement from the european myeloma network philippe moreau 1 pieter sonneveld 2 mario boccadoro 3 gordon cook 4 ma victoria mateos 5 hareth nahi 6 hartmut goldschmidt 7 meletios a. Chimeric antigen receptors cars are fusion. Multiple myeloma mm is the second most common hematologic malignancy and remains incurable despite the advent of numerous new drugs such as proteasome inhibitors pis immunomodulatory agents imids and monoclonal antibodies. Potential and currently studied settings for the use of car chimeric antigen receptor t cell therapy in the management of multiple myeloma through the natural history of the disease.

Preclinical studies suggest that bb2121 a chimeric antigen receptor car t cell therapy that targets b cell maturation antigen bcma has potential for the treatment of multiple myeloma. Chimeric antigen receptor t cell therapy for multiple myeloma.